Synthesis and kinetic resolution of N-Boc-2-arylpiperidines.
نویسندگان
چکیده
The chiral base n-BuLi/(-)-sparteine or n-BuLi/(+)-sparteine surrogate promotes kinetic resolution of N-Boc-2-arylpiperidines by asymmetric deprotonation. The enantioenriched starting material was recovered with yields 39-48% and ers up to 97 : 3. On lithiation then electrophilic quench, 2,2-disubstituted piperidines were obtained with excellent yields and enantioselectivities.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 69 شماره
صفحات -
تاریخ انتشار 2014